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Inventi Impact: Pharm Tech

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  • Inventi:ppt/32103/20
    Development of 20(S)-Protopanaxadiol-Loaded SNEDDS Preconcentrate Using Comprehensive Phase Diagram for the Enhanced Dissolution and Oral Bioavailability
    Research 2020 : July - September
    Young Hoon Kim, Yu Chul Kim, Dong-Jin Jang, Kyoung Ah Min, Jenisha Karmacharya, Thi-Thao-Linh Nguyen, Han-Joo Maeng, Kwan Hyung Cho

    In this study, we aimed to develop a 20(S)-protopanaxadiol (PPD)-loaded self-nanoemulsifying\ndrug delivery system (SNEDDS) preconcentrate (PSP) using comprehensive ternary phase diagrams for\nenhanced solubility, physical stability, dissolution, and bioavailability. Capmul MCM C8 and Capryol\n90 were selected as the oil phase owing to the high solubility of PPD in these vehicles (>15%, w/w).\nNovel comprehensive ternary phase diagrams composed of selected oil, surfactant, and PPD were\nconstructed, and the solubility of PPD and particle size of vehicle was indicated on them for\nthe effective determination of PSP. PSPs were confirmed via particle size distribution, physical\nstability, and scanning electron microscope (SEM) with the dispersion of water. The optimized PSP\n(CAPRYOL90/Kolliphor EL/PPD = 54/36/10, weight%) obtained from the six possible comprehensive\nternary phase diagrams showed a uniform nanoemulsion with the particle size of 125.07..................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Kim, Young Hoon, et al. \"Development of 20 (S)-Protopanaxadiol-Loaded SNEDDS\nPreconcentrate Using Comprehensive Phase Diagram for the Enhanced Dissolution and Oral Bioavailability.\"\nPharmaceutics 12.4 (2020): 362.\nhttps://doi.org/10.3390/pharmaceutics12040362\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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